Red Blood Cell Passage Through Narrow Capillaries: Effects of Stiffness and Shape

Seminar/Forum

Red Blood Cell Passage Through Narrow Capillaries: Effects of Stiffness and Shape

Seminar Room, Level 3
Mechanical Engineering, Bldg 170

Parkville campus

Booking not required

Further Details

T: (03) 8233 7987

nbaxter@unimelb.edu.au

Red blood cells (RBCs) traverse vasculature with diameters as small as 3 micrometres to supply oxygen and nutrients throughout the body. In this work, experiments and modelling were used to examine the separate effects of cell shape and stiffness on the ability of RBCs to traverse small constrictions. The effects of pathological conditions, such as malaria were interrogated. We show that changes to surface area to volume ratio are more important than stiffness and could be targeted for therapies.

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