Biomedical Engineering Seminar: Patient-Specific Neural Mass Modelling of Focal Seizures
Building 193, Electrical and Electronic Engineering Building
T: (03) 8344 6606
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The aim of this research seminar is to propose a framework to obtain patient-specific models for people with epilepsy who have focal seizures. Different biologically plausible models of the brain are reviewed, including methods that have been used to analyse and identify them. A novel framework is proposed to construct patient-specific models using Electrocorticographic (ECoG) data. To this end, the Jansen and Rit (1995) model of a cortical column is extended such that the model emulates transitions to and from seizures states. The extended model will be fitted (by an identification and validation method) to ECoG data. This framework may help us to describe the underlying mechanisms of initiation and termination of seizures in individual patients. Our next goal is to generalise our proposed frameworks by interconnecting the extended models, and fit them to multi-channel ECoG data to investigate spatio-temporal pattern of spreading seizures in the cortex of individual patients. The outcome of this research can be used to investigate optimal electrical stimulation strategies to prevent or stop seizures.