Biomedical Engineering Seminar: Cellular Dynamics of Nanoengineered Particles
Building 193, Electrical and Electronic Engineering Building
T: (03) 8344 6606
Layer-by-layer (LbL)-assembled carriers have recently emerged as a promising class of materials for applications in biology with studies progressing from in vitro to in vivo. The versatility of LbL assembly coupled with particle templating allows the generation of capsules with specific properties (eg., stimuli-responsive, efficient cargo encapsulation), thus offering new opportunities in drug delivery. In this presentation, the interactions between human cancer cells and the LbL capsules will be discussed. The focus will be placed on the internalization and intracellular trafficking of these particles. Based on the cellular interactions, several approached for drug encapsulation and controlled intracellular released will also be addressed in the talk. Taken together, these studies have highlighted the importance of understanding the complex cellular dynamics of particles in advanced drug delivery.