Biomedical Engineering Seminar: Modelling Electrical Stimulation in Neural Masses
Building 193, Electrical and Electronic Engineering Building
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The aim of this project is to model the effect of electrical stimulation on local neural activity in the brain. This will contribute to a larger project of systematic controlling of epileptic seizures through a model-based strategy. Epileptic seizures are the result of an uncontrolled burst of electrical activity in the brain, which can lead to convulsions or loss of consciousness. The most common form of treatment for epilepsy is via drugs. However, they are not effective for approximately one third of epilepsy patients. An alternative therapy is to apply electrical stimulation to control abnormal brain activity.
In order for the developed model to be clinically applicable, the appropriate functional form and physiological parameters need to be identified to make it applicable to cortical tissue stimulated by surface electrode arrays. The whole model will then be validated using data from cortical tissue in epilepsy surgical patients that is stimulated by surface electrode arrays. The resulting model would be helpful in treating patients suffering from neurological disorders such as epilepsy and Parkinson's disease.