Global Analysis of Cell Signaling Pathways by Quantitative Phosphoproteomics
Walter and Eliza Hall Institute
1g Royal Parade, Parkville
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The major scientific focus area for the Olsen group has been quantitative, high-resolution mass spectrometry-based proteomics with an emphasis on mass spectrometric technology developments and biological applications. The group has a strong interest in applying the proteomics technology developed to systems-wide analyses of dynamic post-translational modifications (e.g. phosphorylation, SUMOylation, and acetylation) that regulate cell signal transduction pathways. In particular, we are continuously developing the phosphoproteomics technology with the aim to be more robust, reproducible, and rapid. The group is also actively developing and applying large-scale quantitative interaction proteomics screens using high-resolution mass spectrometry as the read-out.
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