Identification of the critical p53 tumour suppression mechanisms in vivo
Walter and Eliza Hall Institute
1g Royal Parade, Parkville
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P53 is the most important gene in human cancer; despite this it remains unclear which of the process(es) activated transcriptionally by p53 are critical for its tumour suppressive function. Although apoptosis, cell cycle arrest and cell senescence have been implicated, total abrogation of these processes revealed that this is not the case, opening the question of which processes are in fact critical. Researchers have resolved this using innovative sensitized shRNA/CRISPR library screens. Researchers findings demonstrate that:
p53 is such a potent tumour suppressor precisely because it can activate so many diverse cellular responses that inhibit neoplastic transformation and expansion of nascent malignant cells, and, most excitingly
that coordination of DNA repair constitutes the most important process activated by p53 for tumour suppression.
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