The Role of Structural Analysis in Biological Discovery: Illustration, Explanation or Illumination?
Walter and Eliza Hall Institute of Medical Research
1g Royal Parade
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The analysis of protein structure is now central to many aspects of the biological discovery process and its application to biomedical research. This seminar will address different ways in which the understanding of protein structure can inform biological investigation. For example, the determination of the first structure of an RHS-repeat-containing protein enabled the prediction of function for this previously mysterious protein family. In contrast, the determination of protein structures from the human pathogen Mycobacterium tuberculosis has enabled the rationalization of previous biochemical and genetic data, and may lead to the identification of antibacterial compounds with novel modes of action compared to current antibiotic therapies.
No registration is required.