Interrogating the Complex Receptor Structures that Support Transmembrane Signalling in Immunity
Walter and Eliza Hall Institute of Medical Research
1g Royal Parade
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The Call laboratory studies the relationships between structure and activation in multi-subunit cell-surface receptors that control key functions in immunity. For many of these receptors, the structures of extracellular regions and their interactions with activating ligands are well understood, and the major intracellular biochemical cascades that follow from ligand-induced activation are thoroughly catalogued. What is almost universally missing from this picture is a detailed understanding of the molecular changes that couple ligand binding to signal initiation across the barrier of the cell membrane. The membrane-spanning regions of these receptor proteins play crucial roles in building functional complexes and provide the direct physical linkages between extracellular and intracellular domains, yet little is known about the structures they form in the membrane and how these contribute to signalling and regulation.
This seminar will cover recent progress from the lab in understanding the membrane-embedded structures of the T cell receptor, natural killer cell receptors and antibody Fc receptors and describe how new methodological advances are being applied to other important systems.
No registration is required.