Transcriptional Diversity in Macrophage Populations Throughout the Pathogenesis of Rheumatic Disease
Seminar Room 2
Walter and Eliza Hall Institute of Medical Research
1g Royal Parade
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Over the past 16 years, Professor Harris Perlman’s area of interest has centered on rheumatic disease. His laboratory focuses on two facets of rheumatology; the role of co-morbidities in rheumatoid arthritis (RA) including atherosclerosis and obesity and the role that macrophage heterogeneity in the target organs (synovium, kidney, skin and lung) plays in the pathogenesis and remission of RA, systemic lupus erythematosus (SLE), and systemic sclerosis (SSc). These studies utilize novel mouse models and techniques developed in his laboratory. His lab is now comparing data observed in murine models with biopsy tissue from rheumatic disease patients. Since he became the Chief of Rheumatology, he has created a central Biorepository for peripheral blood, serum and tissue (Biopsy) samples from RA, PsA, OA, SLE, and SSc patients including synovium, skin, kidney lung and esophagus. Whole tissue and individual populations of immune cells are being analyzed from these biopsies via RNA seq. Thus, by using the cutting-edge technologies that he developed including micro-MRI to evaluate atherosclerotic lesions, bone destruction and inflammation, Luminex-based gene arrays and multiparameter flow cytometry, coupled with current state-of-the-art technology such as RNA seq and single cell RNA seq, Professor Perlman believes that his data has the potential to be paradigm shifting and transformative for the field of rheumatic disease.
No registration is required.