Single Cell RNA Sequencing Technologies: The Advantages of Being Single amongst Singles
Walter and Eliza Hall Institute
1g Royal Parade
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In the past two decades high throughput DNA sequencing technologies have emerged and have rapidly become available to labs across the world. This technological breakthrough has given rise to many different applications that allowed research to shift from candidate gene approaches to unbiased genome wide studies. This talk will focus on RNA sequencing technologies, which look at gene expression. While initial studies were restricted to population based transcriptome analysis (due to the large amount of RNA required for sample preparation), recent advances now allow the study of single cell transcriptomes. The concepts and innovations behind theses ultra-low input sample preparation strategies are presented as well as some basic computational approaches to deal with the complex and noisy data. Single cell RNA sequencing opens a whole new field in biology by allowing the study of cell-to-cell heterogeneity in gene expression on a genome wide level.
Dr Daniela Zalcenstein is part of the Naik Laboratory in the Molecular Medicine division.
No registration is required.