Human Functional Genomics


Human Functional Genomics

Davis Auditorium
Walter and Eliza Hall Institute


1g Royal Parade

Booking not required

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T: (03) 9345 2555

Interrogating the function of genes in development, health and disease has mainly been carried out in mouse models. With the advent of cell reprogramming, a process that turns a somatic cell into a pluripotent stem cell that is immortal and able to differentiate into every cell type of the human body, and the rise of CRISPR-assisted genome editing, a technology that permits gene knock-out as well as introduction or correction of mutations associated with human disease, human functional genomics is now possible.

In this presentation Professor Ernst Wolvetang will give examples how he used these approaches to investigate a range of neurological diseases and now also the ageing process. He will demonstrate how in vitro organoid based culture platforms can permit insight into more complex disease phenotypes and show how single cell transcriptomics help to reveal the diversity and complexity of early human brain development. Finally he will also discuss the possibilities and challenges associated with the use of genome edited human iPSC in drugscreening and personalized precision medicine .

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