Dr Twycross was a Research Fellow in Therapeutics at St Christopher’s Hospice, London in the 1970’s. He subsequently became Medical Director of Sir Michael Sobell House, Churchill Hospital, Oxford and from 1988–2001, Clinical Reader in Palliative Medicine, Oxford University. Between 1988-2005 he was Head of the World Health Organization Collaborating Centre for Palliative Care.
He has taught in nearly 50 countries, and has written some 300 articles, chapters and editorials, and is the author/editor of several widely acclaimed textbooks, including the Palliative Care Formulary. He has received numerous lifetime achievement and other awards from professional organisations.