Fungal Diseases in Humans and the Development of New Antifungal Drugs
Walter and Eliza Hall Institute
1g Royal Parade
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The fungi, our closest microbial relatives, are amongst the most common causes of human disease, but usually these are not life threatening. A small group of fungal species is able to spread throughout the body, and those cases are usually fatal unless treated with antifungal agents (and sometimes surgery). However, the chemical class options for fungicides are limited, in part due to the largely shared biochemistry between humans and fungi, and those that are have either toxic side effects or resistance emerges rapidly. A number of new approaches have been taken towards finding ways to control fungi pharmacologically. This presentation will cover what these approaches are, and the advantages and disadvantages of each.