Biomedical Engineering Seminar: The effect of morphology and intrinsic electrophysiology in shaping retinal ganglion cell responses
Building 193, Electrical and Electronic Engineering
T: (03) 8344 6606
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Retinal ganglion cells (RGCs) display differences in their morphology and intrinsic electrophysiology. Matias Maturana will explore realistic, morphologically correct models of 200 ON and OFF RGCs, and test ionic channel densities in morphological compartments that are necessary to capture experimentally recorded phenomena. He will investigate the effect of the cell’s morphology on its impulse waveform, using the first and second-order time derivatives as well as phase plot features. Matias Maturana proposes that a combination of morphological and ionic features shape the cell’s impulse response and confirm that by simulations. In addition, he explore the ability of the constrained models of RGCs to respond to high frequency bi-phasic pulse train stimulation and show that cells’ morphology plays an important role in shaping cell responses.