Biomedical Engineering Seminar: MRI studies of cortical folding development
Old Metallurgy Building
T: (03) 8344 6606
The pattern of cortical folding that is unique to each human brain arises during development from a series of physiological and biomechanical factors that remain the focus of on-going research. To analyse patterns of cortical folding, MRI has been widely used in the computation of metrics based on morphometric analyses.
This talk will firstly present the use of a Spherical Harmonic representation of the cortical surface to measure cortical complexity, including prediction of intermediate folding states during development. Secondly, a modified gyrification index computed using the Laplace Beltrami operator will be presented. This method uses the intrinsic geometry of the cortex, rather than being constrained by slice orientation. Cortical folding is quantified using a metric based on eigenvalues of the Laplace Beltrami operator. It will be demonstrated that such metrics are useful measures of cortical gyrification and complexity across key developmental time-points, using MRI of a fetal sheep model at different gestational ages.