Transformation of normal cell into neoplastic and metastatic phenotypes is aided by several surrounding components that are collectively known as the tumor microenvironment.

The composition of this micro-environment is frequently altered to support tumor progression. To overcome hypoxic conditions tumor cells secrete angiogenic growth factors that enhance neovascularization.

Most antitumor agents are cytotoxic in nature, designed mainly to prevent tumor growth. However, an ideal therapeutic agent should exhibit selectivity and minimal toxicity.

As the role of the tumor microenvironment in disease progression is better understood, more effective therapeutic agents can be developed.

This presentation will highlight the role of microenvironment factors in tumor growth and metastasis and will introduce various investigative tools developed by Merck Millipore to study this process.